SAN FRANCISCO @ INDIANAPOLIS (SF -5.5, 46.5) NFL ODDS, NFL PREDICTIONS, NFL PREVIEWS 49ers vs Colts Free Pick, NFL Free Picks, NFL Predictions 12/22/25 49ERS @ COLTS 12/21/25 The San Francisco 49ers and Indianapolis Colts will have the chance to help themselves on the field when they meet tonight in Indianapolis. This comes after having the chance to watch division rivals try to hold serve in a close playoff battle.   With the Seahawks (12-3) and Rams (11-4) ahead of them, th