USC vs Notre Dame (ND -10.5, 59.5) CFB ODDS, CFB PREDICTIONS, CFB PREVIEWS USC vs Notre Dame, CFB Picks, CFB Free Picks, CFB Predictions 10/18/25 USC vs NOTRE DAME – NOTRE DAME STADIUM – SOUTH BEND, IN – 7:30PM   We have a huge game here with playoff implications on the line as the USC Trojans travel to South Bend, IN to play the Notre Dame Fighting Irish.  Notre Dame is a much different team from the team we saw in the first 2 weeks of the season especially on the defensive